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KMID : 1039920150220010027
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Neonatal Medicine
2015 Volume.22 No. 1 p.27 ~ p.33
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Clinical Characteristics of Acute Respiratory Tract Infections in Full-Term Newborns without Risk Factors
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Song Woo-Sun
Song Byung-Jin
Kim Won-Duck
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Abstract
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Purpose: This study evaluated the characteristics and symptoms of full-term new-borns without risk factors who were diagnosed with acute lower respiratory tract infections (ALRI).
Methods: Nasopharyngeal aspirates were obtained from 72 full-term newborns to 30 days of age who were diagnosed with ALRI from September 2011 to November 2013 and analyzed by multiplex real time-polymerase chain reaction (RT-PCR).
Results: Viruses were detected in 60 newborns (83.3%). Single viruses were observed in 56 newborns (77.7%). The most commonly detected viral agent was respiratory syncytial virus (RSV) (63.8%), followed by parainfluenza virus (6.9%), rhinovirus A/B (4.1%), and human coronavirus (2.7%). Clinical diagnoses of ALRI in newborns with a single virus included pneumonia (66.07%), bronchiolitis (30.43%), bronchitis (5.35 %), and croup (1.79%). There were no differences in epidemiological characteristics between RSV and other viruses. However, newborns diagnosed with RSV had prolonged hospitalizations and significantly increased respiratory rates.
Conclusion: Respiratory viruses, especially RSV, are pivotal causes of ALRI in new-borns. Further, studies on RSV severity and vaccination are necessary to reduce hospitalization and mortality of full-term infants.
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KEYWORD
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Full term newborn, Acute lower respiratory tract infection, Multiplex RT-PCR, RSV
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